Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain
نویسندگان
چکیده
a ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, AZ b Banner Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ, 85351, USA c School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands d Department of Psychiatry, University of Oxford, Warneford Hospital, OX3 7JX, Oxford, UK
منابع مشابه
Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation and DNA hydroxymethylation are 2 important epigenetic mechanisms that regulate gene expression in the aging brain. However, very little is known about the levels of markers of DNA methylation and hydroxymethylation in t...
متن کاملP 109: The Potential Preventive-Therapeutic Effects of Flavonol Consumption on Alzheimer\'s Disease
Alzheimer's disease (AD) is considered as the greatest thread to adults aged 65 and older. It stands as the most common cause of dementia, the prevalence of which is around 24 million worldwide. AD is a progressive and degenerative disorder that combats the neurons, leading to impairment of different cognitive functions. AD is characterized by an accumulation of two factors normally present in ...
متن کاملEffect of Memantine on Expression of NAT-Rad18, Rad18 and Sorl1 Genes in Rat Model of Alzheimer\'s Disease
Background and Objective: Dysregulation of long-term expression of non-coding RNAs (lncRNAs) has a potential role in progressive brain disorders such as Alzheimer's disease. This study aimed to analyze the apoptosis and expression of 51A and NAT-Rad18 lncRNAs and their target genes in brain tissue and peripheral blood mononuclear cells (PBMCs) of the rat model of AD, before and after memantine ...
متن کاملEffects of harmalol on scopolamine-induced memory disorders, anxiety and depression like behaviors in male mice: A behavioral and molecular study
Introduction: Harmalol is a dihydrocarboline compound found naturally in several alcoholic beverages and medicinal plants. This study was designed to investigate the effect of harmalol on memory function and its possible mechanisms in a scopolamine-induced memory disorder model. Materials and Methods: Thirty five male mice were randomly divided into five (n=7) group: Control group )normal sali...
متن کاملاثر هشت هفته تمرین استقامتی و تجویز لیتیوم کلراید بر سطح سرمی BDNF رت‌های ماده مبتلا به آلزایمر
Background and Objective: Alzheimer is a neurodegenerative disease in which a reduced memory capacity and numerous changes occur in the patient’s brain. This study was embarked to shed light on the effects of eight weeks of endurance training and lithium chloride administration on brain-derived neurotrophic factor serum levels in female rats with Alzheimer's disease. Materials and Methods: 7...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuroepigenetics
دوره 6 شماره
صفحات -
تاریخ انتشار 2016